1. From the Division of Cardiovascular Medicine (D.R.O, P.A.C., J.H.F.R., M.R.B.), and Centre for Applied Medical Statistics (R.A.P.), University of Cambridge, Cambridge, United Kingdom; and Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom (D.R.O., P.A.C., D.G., S.P.H., N.E.J.W., M.G.).