The Effect of Levarterenol on Polarographic Myocardial Oxygen, the Epicardial Electrocardiogram and Contraction-Reference-Cited by-同舟云学术

The Effect of Levarterenol on Polarographic Myocardial Oxygen, the Epicardial Electrocardiogram and Contraction

Published:1960-01 Issue:1 Volume:8 Page:109-128
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

SAYEN J. J.¹,KATCHER A. H.¹,SHELDON W. F.¹,GILBERT C. M.¹

Affiliation:

1. Edward B. Robinette Foundation, Department of Medicine, the Department of Pathology and the Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia, Pa

Abstract

In open-chest dogs it was found that levarterenol produced primary RS-T segment depression in epicardial surface electrocardiograms together with increases of ventricular muscle contractility. These effects occurred in nonischemic, regionally ischemic, and hypoxic myocardium and were accompanied by rises of polarographic myocardial oxygen and a reddening of coronary venous blood in all but the lowest dosages. The findings are discussed in the light of the pertinent experimental literature.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.8.1.109

Reference60 articles.

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4. Motion picture studies of ventricular muscle dynamics in experimental localized ischemia, correlated with myocardial oxygen tension and electrocardiograms. Proc. Amer. Soc. Clin. Invest;SAYEN T. J.;J. Clin. Invest.,1954

5. Intramyocardial and epicardial electrocardiograms in acute localized ventricular ischemia correlated with oxygen tension determinations and with muscle dynamics;SAYEN J. J.;Proc. Amer. Fed. Clin. Research: Clin. Res. Proc.,1955

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