1. From the Terrence Donnelly Heart Centre, St Michael’s Hospital, Toronto, Ontario, Canada (A.B., H.A.L., N.F.); Department of Medicine (A.B., H.A.L, N.F.) and Department of Surgery (T.G.), University of Toronto, Toronto, Ontario, Canada; Duke Clinical Research Institute, Durham, North Carolina (A.B., S.O.B.); University of Ottawa, Ottawa, Ontario, Canada (P.G.); and Peterborough Regional Health Centre, Peterborough, Ontario, Canada (W.B.).