Author:
Albertini R,Binia A,Otsuka Y,Carretero O A
Abstract
Previous studies have suggested that angiotensin II and sodium can act as alternative mechanisms in maintaining high blood pressure in chronic renovascular hypertension, In the present study, exchangeable sodium was measured in rats in which angiotensin II has been confirmed or excluded as the main cause of the hypertension. To determine the degree of participation of angiotensin II in the maintenance of the high blood pressure, we studied the mean blood pressure response to an angiotensin antagonist (1-Sar-8-Ala-angiotensin II) and to a converting enzyme inhibitor (SQ20,881). Rats with a decrease in blood pressure of less than 20 mm Hg, in response to both inhibitors, were classified as nonresponders; those with a decrease of 20 mm Hg or more, as responders. Fifty percent of the rats with two-kidney hypertension were nonresponders, and they had lower blood pressure and plasma renin activity than the responders. Further, these two-kidney, hypertensive, nonresponder rats had normal exchangeable sodium. The two-kidney hypertensive responders, on the other hand, had significantly higher exchangeable sodium than both the two-kidney, hypertensive nonresponders and the two-kidney control rats. These results suggest that angiotensin II and exchangeable sodium do not play a major role in the maintenance of the high blood pressure in the two-kidney hypertensive nonresponders. However, there appears to be an abnormal relationship between renin and exchangeable sodium in the two-kidney hypertensive responders that could contribute to the maintenance of the hypertension.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference23 articles.
1. Contrasting exchangeable sodium in rats with different types of Goldblatt hypertension;Tobian L;Am J Physiol,1969
2. Sodium balance during the development of experimental hypertension;Swales JD;J Lab Clin Med,1972
3. Hypertension of Renal Origin: Evidence for Two Different Mechanisms
4. Effect of angiotensin antagonist in rats with acute, subacute and chronic two-kidney renal hypertension;Carretero OA;J Lab Clin Med,1978
5. Evidence for a factor other than angiotensin and positive sodium balance in the pathogenesis of chronic renal hypertension;Otsuka Y;Physiologist,1977
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