1. From the Departments of Medicine and Pharmacology (D.J.K., S.V., S.M.P., M.K., M.B.K., Z.X., D.M., J.I.S.), Medical University of Ohio, Toledo, Ohio; and Laboratory of Cardiovascular Science (N.I.K., E.G.L., O.V.F., A.Y.B.), National Institute on Aging, Baltimore, Md.