Author:
Harris R J,Bayhan M,Branston N M,Watson A,Symon L
Abstract
The effect of indomethacin (3mg/kg IA) preloading on the pathophysiology of a model of acute cerebral ischaemia has been tested. Primates anaesthetised with alpha-chloralose were used. Indomethacin reduced basal blood flow by 39% and reduced CO2 reactivity by 71%. Water content changes of the cerebral cortex and relationships between blood flow and extracellular potassium (Ke), and calcium (Cae) activities have been measured. Indomethacin infusion did not effect the water content of the left side but there was more water in all regions of the right hemisphere which were rendered ischaemic. There water increases were significant for blood flows greater than 5ml/100g/min in exposed areas. There was a significant increase in the flow thresholds for change in Ke and Cae. Possible mechanisms for these changes have been discussed.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)
Reference23 articles.
1. Transient ischemic attacks: Natural history and anticoagulation
2. Whisnant JP: Indications for medical and surgical therapy for ischemic stroke. In Thompson RA Green JR (eds) Advances in Neurology Vol. 4. Stroke. New York Raven Press pp 133-144 1977
3. XI. Transient focal cerebral ischemia: Epidemiological and clinical aspects;Hcyman A;Stroke,1974
4. Central Statistical Office of Finland: Life tables 1966-1970. Government printing centre Helsinki 1974
5. Surgical and Anticoagulant Therapy of Occlusive Cerebrovascular Disease
Cited by
48 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献