1. From the Framingham Heart Study, MA (M.N., R.S.V., V.X.); Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA (M.N.); Departments of Biostatistics (D.M.E., V.X.), Epidemiology (R.S.V., V.X.), and Sections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine (R.S.V., V.X.), Boston University School of Public Health, MA.