1. From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA (K.H.P.); University of Pittsburgh Medical Center, Pittsburgh, PA (K.H.P.); University of Texas Health Science Center at Houston (J.V.); University of Texas Medical Branch at Galveston (J.V.); and University General Hospital, Houston, TX (J.V.).