Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals

Author:

Singh Meera V.1,Kotla Sivareddy23,Le Nhat-Tu243,Ae Ko Kyung23,Heo Kyung-Sun25,Wang Yin2,Fujii Yuka2,Thi Vu Hang2,McBeath Elena2,Thomas Tamlyn N.2,Jin Gi Young2,Tao Yunting2,Medina Jan L.2,Taunton Jack6,Carson Nancy7,Dogra Vikram7,Doyley Marvin M.8,Tyrell Alicia9,Lu Wang9,Qiu Xing9,Stirpe Nicole E.1,Gates Kathleen J.1,Hurley Christine10,Fujiwara Keigi2,Maggirwar Sanjay B.1,Schifitto Giovanni11,Abe Jun-ichi2

Affiliation:

1. Departments of Microbiology and Immunology (M.V.S., N.E.S., K.J.G., S.B.M.), University of Rochester, NY.

2. Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).

3. Radiology Research (S.K., N.-T.L., K.A.K.), Houston Methodist Research Institute, TX.

4. Departments of Cardiovascular Sciences (N.-T.L.), Houston Methodist Research Institute, TX.

5. Institute of Drug Research and Development, Chungnam National University, Daejeon, Republic of Korea (K.-S.H.).

6. Department of Cellular and Molecular Pharmacology, University of California-San Francisco (J.T.).

7. Imaging Sciences (N.C., V.D.), University of Rochester, NY.

8. Electrical and Computer Engineering (M.M.D.), University of Rochester, NY.

9. Biostatistics and Computational Biology (A.T., W.L., X.Q.), University of Rochester, NY.

10. Medicine, Infectious Disease (C.H.), University of Rochester, NY.

11. Neurology (G.S.), University of Rochester, NY.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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