1. From the Department of Pharmacology (K.M., K.I., M.K., C.Y.-N.), Department of Cardiovascular Medicine (H.Y., H.M.), and Department of Dermatology (M. Matsuki, K.Y.), Kyoto Prefectural University of Medicine, Kyoto; and the Department of Pharmacology, Osaka Medical College (D.J., S.T., M. Miyazaki), Osaka, Japan. Drs Matsuki and Yamanishi are now at the Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan.