Evidence for the Renal Conversion of Angiotensin I in the Dog-Reference-Cited by-同舟云学术

Evidence for the Renal Conversion of Angiotensin I in the Dog

Published:1970-09 Issue:3 Volume:27 Page:321-324
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

FRANKLIN W. G.¹,PEACH M. J.¹,GILMORE J. P.¹

Affiliation:

1. Departments of Physiology and Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22903

Abstract

Experiments were carried out on perfused canine kidneys in situ to determine if renal conversion of angiotensin I occurs. Various concentrations of decapeptide produced an immediate increase in renal vascular resistance when injected directly into the renal artery. Since the decapeptide is biologically inactive, the increased resistance was interpreted as indicating generation of angiotensin II. The extent of renal conversion of angiotensin I to angiotensin II was estimated to be approximately 19% in the normal dog. This percent conversion was reduced to about 10% in dogs maintained on high salt and DOCA for 7 to 10 days.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.27.3.321

Reference7 articles.

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