1. From the Department of Pharmacology, Chemotherapy and Medical Toxicology (E.N., M.O.C.), School of Medicine, Milan University, Italy; Istituto Auxologico Italiano (E.N., M.O.C.), Italy; Department of Preclinical Sciences (E.C.), Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milan University, Italy; E. Medea Scientific Institute (E.C.), Bosisio Parini, Italy; and The Wolfson Institute for Biomedical Research (S.M.), University College London, UK.