1. From the Department of Pharmacology and Toxicology and the Cardiovascular Research Center (Z.-D.G., J.A.A.), Medical College of Wisconsin, Milwaukee, Wis; the Departments of Medicine (Cardiology) (R.G.B., Y.G., S.D.P., R.B., J.A.A.) and Pathology (S.S.M.), University of Louisville, Louisville, Ky; and the Department of Molecular Pharmacology and Cellular Biophysics (W.K.J.), University of Cincinnati, Cincinnati, Ohio.