1. From the Centre for Clinical Pharmacology, BHF Laboratories (V.A., C.T.L.T., F.A., J.M.L., P.V.), University College London; and the Department of Cellular and Molecular Sciences (V.A., C.T.L.T., F.A., G.S.J.W., J.M.L.), St George’s Hospital Medical School, London, United Kingdom.