Recipes for Creating Animal Models of Diabetic Cardiovascular Disease

Author:

Hsueh Willa1,Abel E. Dale1,Breslow Jan L.1,Maeda Nobuyo1,Davis Richard C.1,Fisher Edward A.1,Dansky Hayes1,McClain Donald A.1,McIndoe Richard1,Wassef Momtaz K.1,Rabadán-Diehl Cristina1,Goldberg Ira J.1

Affiliation:

1. From the Division of Endocrinology, Diabetes, and Hypertension (W.H.), and Department of Medicine, Division of Cardiology (R.C.D.), The David Geffen School of Medicine, University of California, Los Angeles; Division of Endocrinology, Metabolism, and Diabetes (E.D.A. and D.A.M.) and Program in Human Molecular Biology and Genetics (E.D.A.), University of Utah, Salt Lake City; Laboratory of Biochemical Genetics and Metabolism (J.L.B.), The Rockefeller University, New York; Department of Pathology and...

Abstract

For more than 50 years, investigators have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of diabetes seen in humans. In particular, accelerated atherosclerosis and dilated cardiomyopathy, the major causes of mortality in patients with diabetes, have been conspicuously absent in many mouse models of the disease. Under the auspices of the NIH, the Animal Models of Diabetic Complications Consortium has worked to address this issue. This effort has focused on the development of mouse models because of the high level of genomic information available and the many well-developed genetic manipulations that may be performed in mice. Importantly, the consortium has also worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications. Finally, for maximum benefits from these animal models in the study of atherosclerosis and of other diabetic complications, the consortium has created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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