1. From the MRC CAiTE Centre (N.J.T., G.D.S., Y.B.-S.), Department of Social Medicine (W.S., Y.B.-S.), University of Bristol; Wales Heart Research Institute (J.C.), University Hospital Heath Park, Cardiff; Clinical Pharmacology Unit (C.M., I.W.), University of Cambridge, Addenbrooke’s Hospital; Department of Epidemiology (J.G.), Statistics and Public Health, Cardiff University Wales College of Medicine; and University Department of Medicine (A.R., G.L.), Royal Infirmary, Glasgow, United Kingdom.