Clinical Validation of Carotid-Femoral Pulse Wave Velocity Measurement Using a Multi-Beam Laser Vibrometer: The CARDIS Study-Reference-Cited by-同舟云学术

Clinical Validation of Carotid-Femoral Pulse Wave Velocity Measurement Using a Multi-Beam Laser Vibrometer: The CARDIS Study

Published:2024-09 Issue:9 Volume:81 Page:1986-1995
ISSN:0194-911X
Container-title:Hypertension
language:en
Short-container-title:Hypertension

Author:

Badhwar Smriti¹^ORCID,Marais Louise¹,Khettab Hakim²^ORCID,Poli Federica¹^ORCID,Li Yanlu³⁴^ORCID,Segers Patrick⁵^ORCID,Aasmul Soren⁶,de Melis Mirko⁶^ORCID,Baets Roel³⁴^ORCID,Greenwald Steve⁷^ORCID,Bruno Rosa Maria¹²⁸^ORCID,Boutouyrie Pierre¹²⁸^ORCID

Affiliation:

1. Paris Cardiovascular Research Center (PARCC) Institut National de la Santé Et de la Researche Médicale (INSERM), Paris, France (S.B., L.M., F.P., R.M.B., P.B.).

2. Hôpital européen Georges-Pompidou (HEGP), Assistance publique-Hôpitaux de Paris (APHP), Paris, France (H.K., R.M.B, P.B.).

3. Photonics Research Group, Ghent University-imec, Belgium (Y.L., R.B.).

4. Center for Nano- and Biophotonics, Ghent University, Belgium (Y.L., R.B.).

5. IBiTech- BioMMedA, Ghent University, Belgium (P.S.).

6. Medtronic Bakken Research Center, Maastricht, The Netherlands (S.A., M.d.M.).

7. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.G.).

8. Université Paris Cité, Faculté de Médecine, France (R.M.B, P.B.).

Abstract

BACKGROUND: Carotid-femoral pulse wave velocity (cfPWV) is the gold standard for noninvasive arterial stiffness assessment, an independent predictor of cardiovascular disease, and a potential parameter to guide therapy. However, cfPWV is not routinely measured in clinical practice due to the unavailability of a low-cost, operator-friendly, and independent device. The current study validated a novel laser Doppler vibrometry (LDV)-based measurement of cfPWV against the reference technique. METHODS: In 100 (50 men) hypertensive patients, cfPWV was measured using applanation tonometry (Sphygmocor) and the novel LDV device. This device has 2 handpieces with 6 laser beams each that simultaneously measure vibrations from the skin surface at carotid and femoral sites. Pulse wave velocity is calculated using ECG for the identification of cardiac cycles. An ECG-independent method was also devised. Cardiovascular risk score was calculated for patients between 40 and 75 years old using the WHO risk scoring chart. RESULTS: LDV-based cfPWV correlated significantly with tonometry (r=0.86, P <0.0001 ECG-dependent [cfPWV LDV_ECG ] and r=0.80, P <0.001 ECG-independent [cfPWV LDV_w/oECG ] methods). Bland-Altman analysis showed nonsignificant bias (0.65 m/s) and acceptable SD (1.27 m/s) between methods. Intraobserver coefficient of variance for LDV was 4.7% (95% CI, 3.0%–5.5%), and interobserver coefficient of variance was 5.87%. CfPWV correlated significantly with CVD risk (r=0.64, P <0.001; r=0.41, P =0.003; and r=0.37, P =0.006 for tonometry, LDV-with, and LDV-without ECG, respectively). CONCLUSIONS: The study demonstrates clinical validity of the LDV device. The LDV provides a simple, noninvasive, operator-independent method to measure cfPWV for assessing arterial stiffness, comparable to the standard existing techniques. REGISTRATION: URL: https://clinicaltrials.gov/study/NCT03446430 ; Unique identifier: NCT03446430.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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