1. From the Department of Medicine and Bioregulatory Sciences (Y.S.-U., K.A., T.Is., S.Yo., R.U., T.M.), Department of Cardiovascular Medicine (S.Ya., T.Iw., K.I., Y.H., M.A., M.S.), and Pharmacology (Y.I.), The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan; ERATO (S.K.), Japan Science and Technology Agency, Kawaguchisi, Saitama, Japan and Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.