1. From the Division of Cardiovascular Medicine, Department of Internal Medicine (K.M., N.E., B.W., K.N., Y.R., K.-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R.), Kobe University Graduate School of Medicine, Kobe, Japan; Division of Clinical Pharmacy (N.E., K.Y.), Kobe Pharmaceutical University, Kobe, Japan; Department of Pathology (T.S.), Tohoku University Graduate School of Medicine, Sendai, Japan.