Affiliation:
1. Johns Hopkins University, Baltimore, MD
2. University of Texas at Austin, TX
3. University of North Carolina, Chapel Hill, NC
4. University of Minnesota Medical School and Lillehei Heart Institute, Minneapolis, MN
Abstract
Background
Evidence regarding the association of lower extremity peripheral arterial disease with quality of life (
QOL
) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community‐derived populations.
Methods and Results
Using data of 5115 participants aged 66 to 90 years from visit 5 (2011‐2013) of the Atherosclerosis Risk in Communities Study, we quantified the associations of ankle‐brachial index (
ABI
) with several
QOL
parameters, including 12‐item Short‐Form Health Survey (
SF
‐12), after accounting for potential confounders using linear and logistic regression models. Peripheral arterial disease defined by an
ABI
<0.90 (n=402), was independently associated with a low
SF
‐12 Physical Component Summary score (−3.26 [95%
CI
−5.60 to −0.92]), compared to the
ABI
reference 1.10 to 1.19 (n=1900) but not with the Mental Component Summary score (−0.07 [−2.21 to 2.06]). A low
ABI
was significantly associated with poorer status of all
SF
‐12 physical domains (physical functioning, role‐physical, bodily pain, and general health) but only vitality out of 4 mental domains. Similarly, low
ABI
values were more consistently associated with other physically related
QOL
parameters (leisure‐time exercise/activity/walking) than mentally related parameters (significant depressive symptoms and hopeless feeling). Lower physical
QOL
was observed even in individuals with borderline low
ABI
(0.90 to 0.99; n=426).
Conclusions
Low
ABI
(even borderline) was independently associated with poor
QOL
, especially for physical components, in community‐dwelling older adults.
QOL
is a critical element for older adults, and thus, further studies are warranted to assess whether peripheral arterial disease‐specific management can improve
QOL
in older populations.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
61 articles.
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