Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke

Author:

Minnerup Jens1,Wersching Heike1,Teuber Anja1,Wellmann Jürgen1,Eyding Jens1,Weber Ralph1,Reimann Gernot1,Weber Werner1,Krause Lars Udo1,Kurth Tobias1,Berger Klaus1,Homberg V.2,Petrovitch A.2,Heuser L.3,Mönnigs P.4,Krogias C.4,Wallner B.5,Hennigs S.5,Ahlers A.6,Sahl H.6,Ranft A.7,Dobis C.5,Brassel F.8,Nolden-Koch M.8,Schmitt H.9,Chapot R.10,Nordmeyer H.10,Schlamann M.11,Weimar C.11,Busch F.12,Busch E.W.13,Sigges E.13,Ruf H.14,Wohlfahrt K.15,Karatschai R.15,Klein B.16,Höhle T.17,Haass A.18,Nasreldein A.18,Büchele B.6,Gahn G.6,Sterker M.19,Hantel T.19,Krämer C.6,Henningsen H.6,Adelt I.16,König M.16,Schmidt C.20,Hofmann A.12,Niederstadt T.21,Unrath M.21,Rehfeldt T.22,Fauser B.23,Pfeiffer A.17,Lowens S.6,Stögbauer F.6,Staudacher T.24,Erdmann P.5,Grotemeyer K.H.25,Spüntrup E.25,Bücke P.26,Wienecke P.27,Faiss J.27,Wolzik-Großmann M.17,Brune N.28,Isenmann S.28,Thomas C.29,Mucha D.29,

Affiliation:

1. From the Department of Neurology (J.M.) and Institute of Epidemiology and Social Medicine (H.W., A.T., J.W., K.B.), University of Münster, Münster, Germany; Department of Neurology (J.E.) and Institute of Radiology, Neuroradiology, and Nuclear Medicine (W.W.), University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany; Department of Neurology, Alfried Krupp Krankenhaus, Essen, Germany (R.W.); Department of Neurology, Städtisches Klinikum Dortmund, Dortmund, Germany ...

2. Zentralklinik Bad Berka GmbH

3. Knappschaftskrankenhaus Langendreer

4. St. Josef-Hospital Bochum

5. Knappschaftskrankenhaus

6. Städtisches Klinikum

7. Städtische Kliniken

8. Klinikum Duisburg

9. Martin Gropius Krankenhaus

10. Alfried Krupp Krankenhaus

11. Universitätsklinikum Essen

12. St. Josef-Krankenhaus

13. Evangelische Kliniken

14. St. Johannes-Hospital

15. Klinikum Bergmannstrost

16. St. Marien-Hospital

17. Evangelisches Krankenhaus

18. Universitätsklinikum Homburg/Saar

19. Klinikum St.Georg

20. Klinikum Meiningen

21. Universitätsklinikum Muenster

22. Dietrich-Bonhoeffer-Klinikum

23. St. Josef-Hospital

24. Oberschwabenkliniken St. Elisabeth

25. Klinikum Saarbrücken

26. Bürgerhospital

27. Asklepius Fachklinikum

28. Helios Klinikum

29. Heinrich-Braun-Klinikum

Abstract

Background and Purpose— In patients with ischemic stroke, randomized trials showed a better functional outcome after endovascular therapy with new-generation thrombectomy devices compared with medical treatment, including intravenous thrombolysis. However, effects on mortality and the generalizability of results to routine clinical practice are uncertain. Methods— In a prospective observational register-based study patients with ischemic stroke treated either with thrombectomy, intravenous thrombolysis, or their combination were included. Primary outcome was the modified Rankin scale score (0 [no symptoms] to 6 [death]) at 3 months. Ordinal logistic regression was used to estimate the common odds ratio as treatment effects (shift analysis). Propensity score matching was applied to compare patients treated either with intravenous thrombolysis alone or with intravenous thrombolysis plus thrombectomy. Results— Among 2650 recruited patients, 1543 received intravenous thrombolysis, 504 underwent thrombectomy, and 603 received intravenous thrombolysis in combination with thrombectomy. Later time-to-treatment was associated with worse outcomes among patients treated with thrombectomy plus thrombolysis. In 241 pairs of propensity score–matched patients with a proximal intracranial occlusion, thrombectomy plus thrombolysis was associated with improved functional outcome (common odds ratio, 1.84; 95% confidence interval, 1.32–2.57), and reduced mortality (15% versus 33%; P <0.0001) compared with intravenous thrombolysis alone. Results were similar in various sensitivity analyses accounting for missing outcome data and different analytic methods. Conclusions— Results from this large prospective registry show that also in routine clinical care thrombectomy plus thrombolysis compared with thrombolysis alone improved functional outcome and reduced mortality in patients with ischemic stroke. Earlier treatment was associated with better outcomes.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

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