Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure.

Author:

Anand I S1,Ferrari R1,Kalra G S1,Wahi P L1,Poole-Wilson P A1,Harris P C1

Affiliation:

1. Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

This study provides data on plasma hormone levels in patients with severe clinical congestive cardiac failure who had never received therapy and in whom the presence of an accumulation of excess water and sodium had been established. Eight patients were studied; two had ischemic cardiac disease, and six had dilated cardiomyopathy. Mean hemodynamic measurements at rest were as follows: cardiac index, 1.8 l/min/m2; pulmonary wedge pressure, 30 mm Hg; right atrial pressure, 15 mm Hg. Total body water content was 16% above control, extracellular liquid was 33% above control, plasma volume was 34% above control, total exchangeable sodium was 37% above control, renal plasma flow was 29% of control, and glomerular filtration rate was 65% of control. Plasma norepinephrine was consistently increased (on average 6.3 times control), whereas adrenaline was unaffected. Although plasma renin activity and aldosterone varied widely, they were on average above normal (renin 9.5 times control, aldosterone 6.4 times control). Plasma atrial natriuretic peptide (14.3 times control) and growth hormone (11.5 times control) were consistently increased. Cortisol was also increased on average (1.7 times control). Vasopressin was increased only in one patient.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference51 articles.

1. FLUID DYNAMICS IN CHRONIC CONGESTIVE HEART FAILURE

2. Haxhe JJ: Body composition and electrolyte studies in Belcher EH Vetter H (eds): Radioisotopes in Medical Diagnosis. London Butterworths 1971 p 256

3. Davis JWL: Blood volume studies in Belcher EH Vetter H (eds): Radioisotopes in Medical Diagnosis. London Butterworths 1971 p 319

4. Veall N Gibbs GP: The accurate determination of tracer clearance rates and equilibrium distribution volumes from a single injection plasma measurement using numerical analysis in Joekes MA Constable AR Brown NJG Tauxe WN (eds): Radionuclides in Nephrophology. London Academic Press 1982 p 125

5. Evaluation of plasma clearances by synthesis of continuous infusion: Principles and use;Chonacky NJ;J Nucl Med,1986

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