Chemistry of Synthetic Angiotensin

Abstract

A short review is given of the development of synthetic angiotensin. Also discussed are enzymic experiments, showing that production of the synthetic substance leads to valyl-5-angiotensin-II, in which all amino acids are completely in the l -configuration. Small amounts of diastereoisomers in intermediates, like l -valyl- d -tyrosyl- l -valyl- l -histidyl- l -prolyl- l -phenylalanine which was isolated and identified, are completely eliminated during the synthetic process. Valyl-5-angiotensin II-aspartyl-β-amides are very slowly hydrolyzed in aqueous solution to valyl-5-angriotensin II and a small amount of the heptapeptide, H·Arg-Val-Tyr-Val-His-Pro-Phe·OH, with negligible decrease in pressure activity of the solution.