Affiliation:
1. From the Donner Laboratory and the Radiation Laboratory, Division of Medical Physics, University of California, Berkeley, Calif.
Abstract
The alloxanized rabbit fed cholesterol develops extreme hyperlipemia and hypercholesteremia and yet develops a lesser degree of atherosclerosis than does the normal animal fed cholesterol. The concentrations of the S
f
12-30 and S
f
20-30 classes of lipoproteins correlate well with atherosclerosis as finally observed in the alloxanized rabbit, whereas both free and total serum cholesterol correlate negatively with atherosclerosis. In the alloxan-diabetic rabbit, the serum cholesterol is principally carried in the S
f
80-100 and greater classes of lipoproteins, and a metabolic block in the conversion of these lipoproteins to those of S
f
40 and less can be demonstrated.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
52 articles.
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