Mast Cell Chymase Degrades ApoE and ApoA-II in ApoA-I–Knockout Mouse Plasma and Reduces Its Ability to Promote Cellular Cholesterol Efflux-Reference-Cited by-同舟云学术

Mast Cell Chymase Degrades ApoE and ApoA-II in ApoA-I–Knockout Mouse Plasma and Reduces Its Ability to Promote Cellular Cholesterol Efflux

Published:2002-09 Issue:9 Volume:22 Page:1475-1481
ISSN:1079-5642
Container-title:Arteriosclerosis, Thrombosis, and Vascular Biology
language:en
Short-container-title:ATVB

Author:

Lee Miriam¹,Calabresi Laura¹,Chiesa Giulia¹,Franceschini Guido¹,Kovanen Petri T.¹

Affiliation:

1. From the Wihuri Research Institute (M.L., P.T.K.), Helsinki, Finland, Center E. Grossi Paoletti and Institute of Pharmacological Sciences (L.C., G.C., G.F.), University of Milan, Milan, Italy, and Faculty of Biology (M.L.), University of Havana, Vedado, Habana, Cuba.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference37 articles.

1. Mast cell-mediated inhibition of reverse cholesterol transport.

2. Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid.

3. Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase: implications for HDL function

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