1. From the Departments of Medicine, Microbiology, Immunology, and Molecular Genetics, and Human Genetics (X.Wang, P.G., J.W., X.Wu, H.Q., P.W., L.W.C., A.J.L.), University of California, Los Angeles; the Division of Biology (J.L.G.), California Institute of Technology, Pasadena; and the Department of Cardiovascular Molecular Sciences and Technologies (L.X., B.T., R.G., A.C.), Pfizer Global Research & Development, Ann Arbor, Mich.