Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)-Reference-Cited by-同舟云学术

Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)

Published:1968-02 Issue:2 Volume:37 Page:279-306
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

SUTHERLAND EARL W.¹,ROBISON G. ALAN¹,BUTCHER REGINALD W.¹

Affiliation:

1. From the Departments of Physiology and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Abstract

Cyclic AMP (adenosine 3',5'-monophosphate or cyclic adenylate) has now been established as a second messenger mediating many of the effects of a variety of hormones. Several of the metabolic effects mediated by cyclic AMP are discussed, and it is suggested that certain other ("functional" or "mechanical") hormonal effects may be similarly mediated. In particular, the evidence presented supports the hypothesis that the positive inotropic response to the catecholamines is mediated by cyclic AMP. Although knowledge of the biological role of cyclic AMP has not been widely applied clinically, sufficient knowledge has now accumulated to make research in this area desirable.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.37.2.279

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