Affiliation:
1. From the Isotope Laboratory, Presbyterian Medical Center and Children's Hospital, San Francisco, California.
Abstract
A method is described for measuring plasma levels of cardiac glycosides, utilizing their inhibitory effect on the rubidium-86 uptake of human red cells. As little as 0.05 mµg. of digoxin/ml. of plasma produces detectable inhibition, but due to the variable effect of other substances in human plasma the practical limit of the method is 1.0 mµg./ml., about 20 times as sensitive as the duck embryo heart or the C
14
-labeled technics.
Patients on digitalis leaf were found to have much higher circulating levels than patients on digoxin (average value 7.5 mµg./ ml. of digoxin equivalent for digitalis leaf, 0.05 mµg./ml. for digoxin). Patients toxic on digoxin averaged 6 mµg./ml.
Of patients not taking digitalis, 7 per cent had significant levels of digitalis-like substances in their plasma; these were mostly individuals with metastatic carcinoma, severe fluid and electrolyte disturbances, or heart failure. No drug (other than cardiac glycosides) gave consistent high levels by this test.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
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