Affiliation:
1. From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY.
Abstract
Background
—The management of neonates with complex congenital anomalies depends on careful interpretation of arterial blood gas values. Improved interpretation of these oxygen parameters may allow clinicians to avoid unexpected cardiovascular events. This study examined whether systemic oxygen delivery (D
o
2
) can be maximized by the use of indices derived from oxygen saturation measurements in neonates with hypoplastic left heart syndrome.
Methods and Results
—For the single-ventricle heart with both circulations in parallel, we used a previously developed computer simulation to obtain D
o
2
as a function of systemic arterial (Sa
o
2
) and venous (Sv
o
2
) oxygen saturation, arteriovenous oxygen difference (Sa-v
o
2
), or pulmonary-to-systemic flow ratio (Qp/Qs). We also examined the oxygen excess factor, Sa
o
2
/Sa-v
o
2
(Ω). We found that (1) slight increases in Sa
o
2
may be associated with large decreases in D
o
2
. (2) Low values for Sv
o
2
indicate low values for D
o
2
. (3) Curves for Sa-v
o
2
and Qp/Qs are redundant in the data provided. (Qp/Qs, however, provides these data in more physiologically relevant terms.) (4) High values for Qp/Qs (>4) are associated with low D
o
2
. (5) Estimating Qp/Qs from oxygen saturation measurements may result in errors when pulmonary venous oxygen saturation is not available. (6) Maximizing D
o
2
is extremely difficult using Sa
o
2
, Sv
o
2
, and Qp/Qs. (7) A linear relationship exists between Ω and D
o
2
, and this linear relationship is not altered by changes in cardiac output.
Conclusions
—Patients with low Sv
o
2
values require attention. Ideally, after reducing Qp/Qs to <1.5, Ω might be a better index to guide further therapy and maximize D
o
2
. Interventions that increased Ω would be considered beneficial, whereas interventions that decreased Ω would be considered detrimental.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
104 articles.
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