1. From Discovery Research Laboratory (R.Y.-K., T.H., H.A., H.Y., S.M.), Tanabe Seiyaku Co Ltd, Saitama, Japan; Department of Internal Medicine (T.M., T.K., S.S., Y.S.), Institute of Clinical Medicine; and Department of Pharmacology (K.G.), Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.