Influence of Sympathomimetic Pressor Drugs on Arrhythmias Caused by Multiple Stimuli

Author:

GILBERT J. L.1,LANGE GERTRUDE1,McC. BROOKS C.1

Affiliation:

1. Department of Physiology, State University of New York College of Medicine at New York City, Brooklyn, N.Y.

Abstract

A technic of administering successive stimuli to the heart at various ectopic foci was devised. Under normal circumstances the heart had sufficient power of integration to resist disorganization of its action by these multiple stimuli. Methoxamine, mephentermine and metaraminol had less tendency to increase vulnerability to fibrillation than did levarterenol under these conditions of stress. A new compound (Lilly #20522) blocked for a time the arrhythmia-producing action of levarterenol.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference12 articles.

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1. Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart;Adrenergic Activators and Inhibitors;1980

2. Effects of intravenous anesthetic agents on left ventricular function in dogs;American Journal of Physiology-Heart and Circulatory Physiology;1977-01-01

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