Studies of the Cerebral Circulation with Labeled Erythrocytes in Healthy Man

Author:

NYLIN GUSTAV1,HEDLUNG SVEN1,REGNSTRÖM OLOF1

Affiliation:

1. Radiosotope Research Laboratory, South Hospital, Stockholm, Sweden.

Abstract

A thorough investigation of 10 healthy males, 26 to 46 years old, has been performed. One and a half ml. of their own erythrocytes, labeled with P 32 , was injected intravenously and dilution curves obtained simultaneously from one carotid artery and the two jugular bulbs. Thereafter, the same amount of labeled blood was injected into both carotid arteries, following one another, and dilution curves from the two jugular bulbs were simultaneously obtained. A total of seven dilution curves was collected in each case. The percutaneous punctures of the carotids were high enough in the neck so that it is highly probable that the injections were made into the internal carotid arteries. Calculations of the cerebral blood flow and the cerebral blood volume in absolute values were performed. The mean value of the cerebral blood flow amounted to 876 ml/min., i.e., 11.4 per cent of the cardiac output. The pool of the brain was calculated to about 100 ml. When a carotid artery was injected, the appearance and peak concentration times estimated from the dilution curves obtained from the ipsilateral bulbs were the same whether the injection was performed in the right or left side. The corresponding times for the dilution curves obtained from the contralateral bulb agreed, whichever the side on which the injection was performned. They were, however, one second longer than the ipsilateral ones. The determination of circulation time is of diagnostic value, according to an earlier publication. A simplified bloodless method has also been tried.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference27 articles.

1. Studies on Distribution of Cerebral Blood Flow with Thorium B-Labeled Erythrocytes

2. FURTHER STUDIES ON THE CEREBRAL BLOOD FLOW ESTIMATED WITH THORIUM-B-LABELLED ERYTHROCYTES

3. Estimation of cerebral blood flow and cerebral blood pool by aid of labelled erythrocytes. In Cerebral Vascular Diseases, edited by I. S. Wright and C. H. Ililliken. New York;XYLIX G.;Grune & Stratton,1958

4. NYMN G. AND HEDLUND S.: Blood flow and pool in heart Iungs and brain. In Circulation.: Proceedings of Harvey Tercentenary Congress London June 1957 edited by J. McMiehael. London Blackwell 1958.

5. XYLIN G. SILFVERSKIOLD B. P. LOPSTEDT S. REGNSTROM O. AND HEDLUND S.: Studies on cerebral blood flow in man using radioactive labelled erythrocytes. Brain 83: (TT) : 293 1960.

Cited by 57 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3