Reduced atherogenesis in cholesterol-fed diabetic rabbits. Giant lipoproteins do not enter the arterial wall.

Author:

Nordestgaard B G1,Stender S1,Kjeldsen K1

Affiliation:

1. Department of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Denmark.

Abstract

In cholesterol-fed rabbits, alloxan-diabetes has an anti-atherogenic effect, which is associated with severe elevation of plasma triglyceride concentrations. To study this effect, we measured lipoprotein sizes and aortic permeability coefficients for cholesteryl ester and for albumin in hypertriglyceridemic diabetic cholesterol-fed rabbits and in normotriglyceridemic cholesterol-fed rabbits. With the same high cholesterol concentration in plasma, hypertriglyceridemic diabetic rabbits had 70% of plasma cholesterol in very large lipoproteins (diameter greater than 75 nm), whereas normotriglyceridemic rabbits had only about 10% of plasma cholesterol in these giant lipoproteins. The aortic permeability coefficients for cholesteryl ester in hypertriglyceridemic diabetic cholesterol-fed rabbits was only 10% to 50% of that in normotriglyceridemic cholesterol-fed rabbits. Aortic permeability coefficients for albumin did not differ significantly between the hypertriglyceridemic and normotriglyceridemic rabbits. The results suggest that the large size of a major fraction of plasma lipoproteins in the hypertriglyceridemic diabetic cholesterol-fed rabbits is responsible for the relatively low aortic permeability coefficient for cholesteryl ester from plasma and hence for reduced atherogenesis in these animals.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Cited by 112 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3