The Emerging Role of Irisin in Cardiovascular Diseases-Reference-Cited by-同舟云学术

The Emerging Role of Irisin in Cardiovascular Diseases

Published:2021-10-19 Issue:20 Volume:10 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

Fu Jinjuan¹,Li Fangtang¹,Tang Yuanjuan¹,Cai Lin¹,Zeng Chunyu²³⁴⁵,Yang Yongjian⁶^ORCID,Yang Jian⁷

Affiliation:

1. Department of Cardiology The Third People’s Hospital of ChengduAffiliated Hospital of Southwest Jiaotong University Chengdu Sichuan China

2. Department of Cardiology Daping Hospital Third Military Medical University Chongqing China

3. Chongqing Key Laboratory for Hypertension Research Chongqing Cardiovascular Clinical Research Center Chongqing Institute of Cardiology Chongqing China

4. State Key Laboratory of Trauma, Burns and Combined Injury Daping Hospital The Third Military Medical University Chongqing China

5. Department of Cardiology of Chongqing General Hospital Cardiovascular Research Center of Chongqing CollegeUniversity of Chinese Academy of Sciences Chongqing China

6. Department of Cardiovascular Medicine The General Hospital of Western Theater Command PLA Chengdu China

7. Department of Clinical Nutrition The Third Affiliated Hospital of Chongqing Medical University Chongqing China

Abstract

Abstract Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti‐inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia–reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin‐mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/JAHA.121.022453

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