A Comparison of the Cerebral Hemodynamic Response to Aramine and Norepinephrine in the Normotensive and the Hypotensive Subject

Author:

MOYER JOHN H.1,MORRIS GEORGE1,SNYDER HARVEY1,SMITH C. POLK1

Affiliation:

1. From the Cardiac Clinic of the Jefferson Davis Hospital and the Departments of Pharmacology, Surgery, and Medicine, Baylor University College of Medicine, Houston, Tex.

Abstract

Previous observations have demonstrated a depression in cerebral blood flow during controlled hypotension with ganglionic blocking agents. Cerebral blood flow is also decreased when normotensive individuals are made hypertensive by the administration of vasopressor agents. The opposite response is observed when hypotensive individuals are made normotensive by the administration of these same agents, in which circumstance cerebral blood flow is increased.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference7 articles.

1. SCHMIDT C. F.: The Cerebral Circulation in Health and Disease. New York Charles C Thomas 1950.

2. The effects of intramuscular dihydroergocornine on the cerebral circulation in normotensive patients;HAFKENSCHIEL J.;J. Pharmacol. & Exper. Therap.,1950

3. 3MOYER J. H. AND MORRIS G.: Cerebral hemodynamics as affected by controlled hypotension through the use of continuous infusion of ganglionic blocking agents. J. Clin. Investigation. In press.

4. THE EFFECTS OF l-EPINEPHRINE AND l-NOR-EPINEPHRINE UPON CEREBRAL CIRCULATION AND METABOLISM IN MAN 1

5. A COMPARISON OF THE EFFECTS OF l-NOR-EPINEPHRINE, SYNTHETIC l-EPINEPHRINE, AND U.S.P. EPINEPHRINE UPON CEREBRAL BLOOD FLOW AND METABOLISM IN MAN 1

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