Affiliation:
1. From the Medical Service and the Medical Research Division, V.A.H., Hines, Ill.
Abstract
Many patients with edema of congestive cardiac failure, nephrosis, and cirrhosis become refractory to all diuretic therapy. Theoretically, the use in adequate dosage of osmotic diuretics whose action is dependent upon physical factors should augment sodium, chloride, and water excretion from whatever level exists prior to their use. In refractory edema, the effect of other diuretics (via alteration of the metabolic, actively resorbing mechanisms of the tubular cells) on tubular rejection of sodium, chloride, and water should be increased by osmotic diuretics. Mannitol was administered intravenously in large doses to test the effectiveness of osmotic diuretics in refractory edema.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference18 articles.
1. The renal reabsorption and excretion of urea under conditions of extreme diuresis;SHANNON J. A.;Am. J. Physiol.,1938
2. Urinary flow and excretion of solutes during osmotic diuresis in hydropenic man;RAPOPORT S.;Am. J. Physiol.,1949
3. Excretion of solutes and osmotic work during osmotic diuresis of hydropenic man. The ideal and the proximal and distal tubular work; the biological maximum of work;RAPOPORT S.;Am. J. Physiol.,1949
4. Mechanism of mercurial diuresis in hydropenie dogs;BRODSKY Wy.;Am. J. Physiol.,1953
5. VOGL A.: Diuretic Therapy. Baltimore The Williams & Wilkins Co. 1953.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献