The Fixation of Radioactive Digitoxin by Isolated Hearts-Reference-Cited by-同舟云学术

The Fixation of Radioactive Digitoxin by Isolated Hearts

Published:1951-07 Issue:1 Volume:4 Page:100-104
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

SJOERDSMA A.¹,FISCHER C. S.¹

Affiliation:

1. From the Department of Pharmacology, The University of Chicago, Chicago, Ill.

Abstract

The nature of digitoxin fixation in isolated hearts was studied with C 14 labelled digitoxin. Fixation was greatest in the early stages of perfusion. The amount of drug fixed was measured directly. A considerable percentage of the digitoxin in cardiac muscle was changed to other substances. These substances are more firmly bound to the heart than digitoxin.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.4.1.100

Reference9 articles.

1. Biosynthesis of Radioactive Drugs Using Carbon 14

2. SOLLMANN T. H. AND HANZLIK P. J.: Fundamentals of Experimental Pharmacology. San Francisco J. W. Stacy 1939.

3. An Internal Geiger Counter for the Assay of Low Specific Activity Samples of Carbon 14 and other Weak Beta Emitters in Biological Samples

4. 4STRAUB XV.: Lane Lecture: Cardiac Glycosides. Stanford Calif. Stanford University Press 1931.

5. 5FRIEDMAN MI. AND BINE R.: The delay in action of digitalis glycoside (lanatoside C). Proc. Soc. Exper. Biol. & _Med. 67: 533 1948.

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