n-3 Polyunsaturated Fatty Acids, Fish, and Nonfatal Acute Myocardial Infarction

Author:

Tavani Alessandra1,Pelucchi Claudio1,Negri Eva1,Bertuzzi Michaela1,La Vecchia Carlo1

Affiliation:

1. From the Istituto di Ricerche Farmacologiche “Mario Negri” (A.T., C.P., E.N., M.B., C.L.V.) and the Istituto di Statistica Medica e Biometria, Università degli Studi di Milano (C.L.V.), Milan, Italy.

Abstract

Background The relation between n-3 polyunsaturated fatty acids (PUFAs), fish intake, and risk of coronary heart disease is controversial. Methods and Results An Italian case-control study including 507 patients with nonfatal acute myocardial infarction (AMI) and 478 hospital controls found a multivariate odds ratio (OR) of 0.67 (95% CI, 0.47 to 0.95) for the highest n-3 PUFA intake and 0.68 (95% CI, 0.47 to 0.98) for an intake of >1 portion of fish per week compared with ≥2 portions per week. Conclusions Small amounts of n-3 PUFAs may be inversely related to AMI risk in this low-risk population.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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