1. From the Department of Internal Medicine, National Cardiovascular Center, Osaka (N.N., J.M., Y.Y., F.O., W.S., M.K., K.M.); Cardiovascular Division, Kansai Rosai Hospital, Hyogo (M.U.); and Departments of Pharmacy (K.U.) and Biochemistry (K.K.), National Cardiovascular Center Research Institute, Osaka, Japan.