1. From the Research Institute of Public Health (R.M.S., K.N., E.P.-S., S.V., T.H.R., T.-P.T., V.-P.V., H.-M.L., M.V., J.T.S.) and Department of Public Health and General Practice (T.H.R., H.-M.L., J.T.S.), University of Kuopio, Finland; Oy Jurilab Ltd (J.K., U.R.), Kuopio, Finland; Inner Savo Health Centre (J.T.S.), Suonenjoki, Finland; and Department of Clinical Pharmacology (H.E.P.), Rigshospitalet, University of Copenhagen, Denmark.