1. From the Department of Cardiovascular Research, Institute of Physiology (F.C., M.E., B.v.d.L., A.K., C.D.G., H.J., T.F.L.), University of Zurich and Cardiovascular Center, University Hospital, Zurich, Switzerland; Department of Experimental Medicine and Pathology (F.C., P.D.P., M.V.), University “La Sapienza,” Rome and IRCCS Neuromed, Pozzilli, Italy; and Faculty of Biology (M.B., V.U.), University of Konstanz, Germany.