1. From the Center of Excellence on Aging and Departments of Medicine and Aging and Drug Sciences (G.D., F.C., F.S., M.P., A.F., G.C.), University of Chieti G. D’Annunzio Schools of Medicine and Pharmacy, Chieti, Italy; Department of Medicine (S.V.), University of Palermo, Palermo, Italy; and University of Rome La Sapienza (S.B., C.P.), Rome, Italy.