Abstract
The brain is the ultimate adaptive system, a complex network organized across multiple levels of spatial and temporal resolution that is sculpted over several decades via
its interactions with the environment. This review sets
out to examine how fundamental biological processes
in early and late neurodevelopment, in interaction with
environmental inputs, guide the formation of the brain’s
network and its ongoing reorganization throughout the
course of development. Moreover, we explore how disruptions in these processes could lead to abnormal brain
network architecture and organization and thereby give
rise to schizophrenia. Arguing that the neurodevelopmental trajectory leading up to the manifestation of
psychosis may best be understood from the sequential
trajectory of connectome formation and maturation, we
propose a novel extension to the neurodevelopmental
model of the illness that posits that schizophrenia is a
disorder of connectome development
Subject
Biological Psychiatry,Psychiatry and Mental health
Cited by
19 articles.
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