Mesoscale sequence feature modulates AID activity in antibody diversification
Author:
Publisher
China Science Publishing & Media Ltd.
Subject
General Medicine,Biochemistry,Biophysics,Molecular Biology
Link
https://engine.scichina.com/doi/pdf/6B53F3AD34BB4B7FB782AE266D272C46
Reference10 articles.
1. Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell, 2013, 152: 417-429.
2. Di Noia JM, Neuberger MS. Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem, 2007, 76: 1-22.
3. Yu K. AID function in somatic hypermutation and class switch recombination. Acta Biochim Biophys Sin, 2022, 54: 759-766.
4. Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaitė A, Liu M. Sequence-intrinsic mechanisms that target AID mutational outcomes on antibody genes. Cell, 2015, 163: 1124-1137.
5. Wang Y, Zhang S, Yang X, Hwang JK, Zhan C, Lian C, Wang C. Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation. Cell, 2023, 186: 2193-2207.e19.
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