A POSSIBLE ALTERNATIVE AND SAFE ADJUNCTIVE ROLE FORLOCALLY APPLIEDMANGIFERININ PERIODONTAL THERAPY A CLINICAL AND MICROBIOLOGICAL STUDY

Abstract

Background:Periodontal health has great impact on overall oral conditions which reflects subjects health. With the radical change that happened to human diet in the past several decades specially the wide spread of finely processed diet over the raw complex diet, it led to increase in several health problems which among them is the periodontal diseases. The periodontal therapy had been relaying on oral hygiene where a lot of researches where implied on adjunctive products which it could promote tissue healing after scaling and root planning as the prim treatment for such conditions. Many of these products showed side effects on long term use. So, apparently the search of a safe product that fulfil this rule would be a wise choice. Aim: The present study was designed to investigate the clinical and microbiological effectiveness of subgingivally delivered mango extract loaded on oxidized paper points (OPP) as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis. Patients and methods:Thirty subjects with periodontal pockets were selected. For each, one site was randomly assigned to receive SRP+mangiferin, SRP+chlorhexidine and a third site received SRP only. The evaluated clinical outcomes were plaque index, gingival index, sulcus bleeding index, and PPD at baseline, two weeks and one month. Microbial analysis was done to estimate the count of aerobic and anerobic counts and also to assess antimicrobial activities of mangiferin against Porphyromonasgingivalis and Prevotella intermedia as compared to well-known antibiotics. Results: There was an intra-group significant reduction in each of the all clinical indices after 2 and 4 weeks of treatment. There were significant differences in each of PI, GI, and SBI between the negative control group and each of the study and positive control groups. There were no significant differences in these indices between the test and positive control groups. PPD showed no significant inter-group differences at any time points. There was intra-group significant reduction in each of the aerobic and anaerobic bacterial counts. There were no significant inter-group differences in these bacterial counts. Comparison in the inhibition zone of mangiferin and chlorhexidine showed that there was a significant difference favoring the mangiferin against tested organisms. There were significant differences between mangiferin when its inhibition zone was compared to tested antibiotics. Conclusion:These results suggested that mangiferin could be used as a good adjuvant in periodontal therapy and this treatment might improve the clinical parameters and reduce the bacterial count as comparable to the gold standard chlorhexidine treatment.