Unraveling the interplay between chronobiology, circadian rhythm, and gut microbiome dynamics in human health

Abstract

Background: This study investigates the intricate interplay between disrupted circadian rhythms, sleep variations, and gut microbiota dynamics, recognizing their bidirectional influences on human health. The relationships are explored through the brain-gut-microbiota axis, emphasizing the importance of maintaining a harmonious balance for overall well-being. Methods: A selection criteria was determined after a thorough literature review across search engines and databases. SANRA guidelines were followed to draft the manuscript. Objectives: To elicit the interplay between sleep patterns, chronobiology, and circadian rhythm influence the composition and functionality of the gut microbiome in human participants. Results: Disruptions in circadian rhythms impact gut microbiota composition, leading to dysbiosis and pathological mechanisms. Reciprocally, variations in sleep duration and quality influence the diversity and function of the gut microbiome. Identified microbial patterns associated with different circadian phases reveal nuanced connections, highlighting the broader implications of circadian rhythm disruption on human health.