Kolşisin Tedavisi Altinda FMF ve Gut Tanısı Alan Hastalarda B12 Vitamin Değerleri İle Böbrek Fonksiyon Testlerinin Karşılaştırılması

Abstract

FMF (Familial Mediterranean Fever); It is a hereditary disease that manifests itself with recurrent periodically increasing fever and abdominal pain, lung and joint pain. It is defined as an autoinflammatory disease that continues with inflammatory attacks that the body repeats itself due to genetic reasons. GOUT is a hereditary disease that occurs as a result of a disorder of purine metabolism. It is a form of inflammation that causes pain, swelling, redness, tenderness, and increased temperature in the joints. Purine is one of the nitrogenous compounds that break down into uric acid in the body. With the increase in the levels of uric acid in the blood, the uric acid crystallizes and accumulates in the joints, tendons, and surrounding tissues. Colchicine is an alkaloid obtained from the seeds of the Colchicum Autumnale L plant, which is used in the treatment of rheumatic diseases such as FMF and GOUT. It is an antimitotic agent that binds to intracellular tubulin protein and inhibits the polymerization of new microtubules. It shows its effect through microtubules. Colchicine treatment in FMF patients prevents the development of amyloidosis and attacks. Thus, as well as preventing acute attacks, it also slows down the formation of amyloidosis, the most important side effect of the disease. In this review, the studies on the subject are examined. Vitamin B12 and renal function tests were compared in patients with FMF or GOUT who received colchicine therapy.