Affiliation:
1. National Almazov Medical Research Centre
2. Saint Petersburg State University
3. Pavlov First Saint Petersburg State Medical University
4. Gomel State Medical University
Abstract
Among existing genetic and non-genetic models of obesity, the most widely used are the models of diet-induced obesity in rodents due to their relatively easy reproducibility and similarities to human pathogenesis of obesity. Within this review, we provide the analysis of diet-induced obesity models in rats, highlight attractive strengths as well as disadvantages of high-fat diets, fat or sugar choice diets, “cafeteria diets”, and “western diet”. Potential obesogenic mechanisms of the discussed models are analyzed. The directions of further studies required for an increase in reproducibility of experimental diet-induced obesity are proposed.
Publisher
Scientia Publishing House LTD
Reference54 articles.
1. Дедов И.И., Мельниченко Г.А., Шестакова М.В. и др. Национальные клинические рекомендации по лечению морбидного ожирения у взрослых. 3-й пересмотр (Лечение морбидного ожирения у взрослых) // Ожирение и метаболизм. 2018. Т. 15. № 1. C. 53-70.
2. Dedov II, Mel'nichenko GA, Shestakova MV, et al. Russian national clinical recommendations for morbid obesity treatment in adults. 3rd revision (Morbid obesity treatment in adults). Obesity and metabolism. 2018;15(1):53-70. (in Russ) DOI: 10.14341/omet2018153-70.
3. Huang T, Hu FB. Gene-environment interactions and obesity: Recent developments and future directions. BMC Med Genomics. 2015;8(Suppl 1):S2. DOI: 10.1186/1755-8794-8-S1-S2.
4. Симаненков В.И., Тихонов С.В., Ильяшевич И.Г., и др. Эпидемиология, социальные аспекты и патогенез ожирения // Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова. 2017. Т. 9. № 1. С. 21-27.
5. Simanenkov VI. Tikhonov SV, Ilyashevich IG, et al. Epidemiology, social aspects and pathogenesis of obesity. Herald of the Northwestern State Medical University named after I.I. Mechnikov. 2017;9(1):21-27. (in Russ)
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献