MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia-Reference-Cited by-同舟云学术

MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia

Published:2022-09-15 Issue:11 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Hansen Jan N.¹²^ORCID,Brückner Matthias²,Pietrowski Marie J.¹,Jikeli Jan F.³,Plescher Monika¹²,Beckert Hannes¹²,Schnaars Mareike²,Fülle Lorenz⁴,Reitmeier Katharina⁵,Langmann Thomas⁵,Förster Irmgard⁴,Boche Delphine⁶,Petzold Gabor C.¹⁷,Halle Annett¹²⁸

Affiliation:

1. German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany

2. Max-Planck Research Group Neuroimmunology and

3. Minerva Research Group Molecular Physiology, Research Center Caesar, 53175 Bonn, Germany

4. Immunology and Environment, Life and Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany

5. Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University Hospital of Cologne, 50931 Cologne, Germany

6. Clinical Neurosciences and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom

7. Department of Neurology and

8. Department of Neuropathology, University Hospital Bonn, 53127 Bonn, Germany

Abstract

MotiQ is an open-source software for automated quantification of microglial motility and morphology. MotiQ can be applied to in vivo, ex vivo, and in vitro data from confocal, epifluorescence, and two-photon microscopy. MotiQ is not limited to microglia—it can also be applied to other cell types.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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