Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex-Reference-Cited by-同舟云学术

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

Published:2020-05-01 Issue:10 Volume:31 Page:992-1014
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Schaefer Kristina N.¹,Pronobis Mira I.¹,Williams Clara E.²,Zhang Shiping²,Bauer Lauren²,Goldfarb Dennis³⁴⁵,Yan Feng³,Major M. Ben³⁶⁴⁷,Peifer Mark¹²³

Affiliation:

1. Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

2. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

4. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110

5. Institute for Informatics, Washington University School of Medicine, St. Louis, MO 63110

6. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

7. Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110

Abstract

Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. We explore β-catenin transfer from the destruction complex to the E3 ligase, and test models suggesting Dishevelled and APC2 compete for association with Axin.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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